Middle East Cystic Fibrosis Association MECFA

MECFA Blog

Elexacaftor-Tezacaftor-Ivacaftor Associated With Rapid Improvement in Cystic Fibrosis

In patients with cystic fibrosis (CF) with advanced lung disease, initiation of elexacaftor-tezacaftor-ivacaftor is associated with rapid...

Computer-designed Enzyme May Help to Kill P. aeruginosa in Biofilms

An enzyme produced using computer design, in combination with the antibiotic tobramycin, efficiently kills Pseudomonas aeruginosa, a...

Translate Bio Continues Trial of Inhaled Cystic Fibrosis mRNA Despite Setback

Translate Bio says it is continuing its Phase I/II trial of its inhaled mRNA cystic fibrosis (CF) candidate MRT5005 despite it showing a...

Translate Bio’s MRT5005 Shows Safety and Tolerability at Multiple Doses in Trial

Translate Bio’s ongoing Phase 1/2 clinical trial investigating MRT5005, its candidate inhalation therapy for cystic fibrosis (CF), found...

Analysis of GI Tract Finds High CFTR Gene Activity in Small Intestine

Molecular analysis of single cells lining the digestive tract found high CFTR activity — the gene associated with cystic fibrosis (CF) —...

Living with an invisible illness

I often describe the disease I’m living with as an invisible illness. If you walk by me in the grocery store, or see me dropping my...

Microorganisms utilize vile methodology to vanquish antibody that battle cystic fibrosis

University of Montana researchers and their partners have found a slimy strategy used by bacteria to conquer antibiotics and other...

Lonodelestat Safely Blocks Inflammatory Marker in CF Patients in Early Trial

Lonodelestat (also known as POL6014), Santhera Pharmaceuticals’ investigational therapy to treat chronic lung inflammation, was safe and...

Girls With CF Need Reproductive Counseling, Study Asserts

Female adolescents with cystic fibrosis (CF) should be offered contraceptive counseling and informed about pregnancy risks, a long-term...

ELX-02 Restores CFTR Activity in Organoids With G542X Mutations, Study Finds

ELX-02 restored the levels and function of CFTR — the defective protein in CF — in “mini-organs,” or organoids, derived from patients...

Disease Duration, Flare-ups Affect Mental Health of Non-CF Bronchiectasis Patients, Study Finds

VERTEX’S CF BLOCKBUSTER TRIKAFTA EFFECTIVE IN KIDS 6 TO 11 YEARS OF AGE

A case for improved carrier screening

Vertex to Seek Expanded FDA Approval for Trikafta After Positive Child Safety Data

Vertex’s Kaftrio approved for use in Europe and made accessible on the NHS

Age May Affect Outcomes in Lung Transplant Recipients With Cystic Fibrosis

CFF Funding Will Further ContraFect’s Research Into Alternative for Antibiotics

The search for molecular glue in targeted disease control

Vest Therapy Lowers Risk of Hospitalization in Non-CF Bronchiectasis, Study Says

Harvard is working with Boston hospitals to test existing cystic fibrosis drug to help coronavirus p